TargetMol

NMK-TD-100

Product Code:
 
TAR-T28179
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28179-5mg5mg£850.00
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TAR-T28179-50mg50mg£1,661.00
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TAR-T28179-100mg100mg£2,079.00
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Further Information

Bioactivity:
NMK-TD-100 is a microtubule modulating agent with anti-proliferative activity by disrupting microtubule functions through tubulin binding. NMK-TD-100 blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin. Polymerization of tissue purified tubulin into microtubules was inhibited by NMK-TD-100 with an IC50 value of 17.5?0.35 ?M.
CAS:
1252802-38-2
Formula:
C19H17N3O3S
Molecular Weight:
367.42
Purity:
0.98
SMILES:
COc1cc(cc(OC)c1OC)-c1nnc(s1)-c1c[nH]c2ccccc12

References

1. Bhattacharya S, Kumar NM, Ganguli A, Tantak MP, Kumar D, Chakrabarti G.NMK-TD-100, a novel microtubule modulating agent, blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin. PLoS One. 2013 Oct 7;8(10):e76286. doi: 10.1371/journal.pone.0076286. eCollection 2013. PubMed PMID: 24116100; PubMed Central PMCID: PMC3792137.