TargetMol

Onapristone

Product Code:
 
TAR-T28237
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Onapristone, a progesterone receptor antagonist, is used potentially for the treatment of breast cancer, advanced prostate cancer, and inducer of vaginal bleeding.
CAS:
96346-61-1
Formula:
C29H39NO3
Molecular Weight:
449.635
Purity:
0.98
SMILES:
[H][C@@]12CC[C@](O)(CCCO)[C@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C

References

1. Rezai K, Chassard D, Denot C, Proniuk S, Zukiwski A, Gilles E, Ramos HL, Patat A, Bexon A, Lokiec F. A single-dose PK study of onapristone including the effect of food on absorption. Cancer Chemother Pharmacol. 2015 Jul;76(1):171-7. doi: 10.1007/s00280-015-2754-3. Epub 2015 May 26. PubMed PMID: 26006702. 2. Rekawiecki R, Kowalik MK, Kotwica J. Onapristone (ZK299) and mifepristone (RU486) regulate the messenger RNA and protein expression levels of the progesterone receptor isoforms A and B in the bovine endometrium. Theriogenology. 2015 Aug;84(3):348-57. doi: 10.1016/j.theriogenology.2015.03.024. Epub 2015 Apr 1. PubMed PMID: 25976976. 3. Guil-Luna S, Hellm?n E, S?nchez-C?spedes R, Mill?n Y, Mart?n de las Mulas J. The antiprogestins mifepristone and onapristone reduce cell proliferation in the canine mammary carcinoma cell line CMT-U27. Histol Histopathol. 2014 Jul;29(7):949-55. doi: 10.14670/HH-29.949. Epub 2014 Feb 6. PubMed PMID: 24500783. 4. Mann GE, Wathes DC, Robinson RS. The progesterone receptor antagonist, onapristone has differential effects on the timing and control of the luteolytic mechanism depending on timing of administration in sheep. Mol Cell Endocrinol. 2013 Aug 25;376(1-2):1-11. doi: 10.1016/j.mce.2013.06.001. Epub 2013 Jun 7. PubMed PMID: 23748180.