TargetMol

Ono 3403

Product Code:
 
TAR-T28241
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T28241-5mg5mg£850.00
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Further Information

Bioactivity:
Ono 3403 is a synthetic serine protease inhibitor. Ono 3403 inhibits lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production. ONO-3403 also has an antitumor effect on malignant tumors.
CAS:
181586-07-2
Formula:
C26H31N3O8S
Molecular Weight:
545.61
Purity:
0.98
SMILES:
CS(O)(=O)=O.CCOC(=O)CN(CC=C)C(=O)C(C)=Cc1ccc(cc1)C(=O)Oc1ccc(cc1)C(N)=N

References

1. Tumurkhuu G, Koide N, Hiwasa T, Ookoshi M, Dagvadorj J, Abu Shadat Mohammod Noman, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Yokochi T. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 2011 Feb;17(1):97-105. doi: 10.1177/1753425909353641. Epub 2009 Dec 18. PubMed PMID: 20023007. 2. Ohkoshi M, Okuda S. Growth inhibition of mouse autochthonous skin cancer by oral administration of new serine protease inhibitor ONO-3403. Anticancer Res. 2002 Mar-Apr;22(2A):821-3. PubMed PMID: 12014657. 3. Hiwasa T, Kondo K, Nakagawara A, Ohkoshi M. Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines. Cancer Lett. 1998 Apr 24;126(2):221-5. PubMed PMID: 9585070. 4. Ohkoshi M, Denda T, Hiwasa T. Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells. Oncol Rep. 1997 May-Jun;4(3):521-3. PubMed PMID: 21590090.