TargetMol

ONO-0300302

Product Code:
 
TAR-T28245
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28245-5mg5mg£503.00
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TAR-T28245-50mg50mg£2,368.00
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Quantity:
TAR-T28245-100mg100mg£3,661.00
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This product comes from: United States.
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Further Information

Bioactivity:
ONO-0300302 is a slow tight binding LPA1 antagonist (IC50: 0.16 nM) used to treat Benign Prostatic Hyperplasia. ONO-0300302 inhibits significantly an LPA-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over 12 h.
CAS:
856689-51-5
Formula:
C29H35NO5
Molecular Weight:
477.601
Purity:
0.98
SMILES:
COc1cc(cc(OC)c1C)[C@@H](O)[C@@H](CC1Cc2ccccc2C1)Cn1ccc(CCC(O)=O)c1

References

1. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia Masahiko Terakado, Hidehiro Suzuki, Kazuya Hashimura, Motoyuki Tanaka, Hideyuki Ueda, Keisuke Hirai, Masaki Asada, Masahiro Ikura, Naoki Matsunaga, Hiroshi Saga, Koji Shinozaki, Naoko Karakawa, Yuka Takada, Masashi Minami, Hiromu Egashira, Yoshihiro Sugiura, Masanori Yamada, Shinji Nakade, and Yoshikazu Takaoka Publication Date (Web): November 20, 2017 (Letter) doi: 10.1021/acsmedchemlett.7b00383