TargetMol

ONO-AE-248

Product Code:
 
TAR-T28252
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28252-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28252-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28252-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
ONO-AE-248 is a selective agonist of EP3 receptor.
CAS:
211230-67-0
Formula:
C22H36O5
Molecular Weight:
380.525
Purity:
0.98
SMILES:
CCCCC[C@H](OC)C=C[C@H]1[C@@H](CC(=O)[C@@H]1CC=C/CCCC(O)=O)OC

References

1. Nagano T, Nishiyama R, Sanada A, Mutaguchi Y, Ioku A, Umeki H, Kishimoto S, Yamanaka D, Kimura SH, Takemura M. Prostaglandin E(2) potentiates interferon-?-induced nitric oxide production in cultured rat microglia. J Neurochem. 2017 Feb;140(4):605-612. doi: 10.1111/jnc.13926. Epub 2017 Feb 2. PubMed PMID: 27973680. 2. Jones VC, Birrell MA, Maher SA, Griffiths M, Grace M, O'Donnell VB, Clark SR, Belvisi MG. Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2. Br J Pharmacol. 2016 Mar;173(6):992-1004. doi: 10.1111/bph.13400. PubMed PMID: 26639895; PubMed Central PMCID: PMC4831025. 3. Oba K, Hosono K, Amano H, Okizaki S, Ito Y, Shichiri M, Majima M. Downregulation of the proangiogenic prostaglandin E receptor EP3 and reduced angiogenesis in a mouse model of diabetes mellitus. Biomed Pharmacother. 2014 Oct;68(8):1125-33. doi: 10.1016/j.biopha.2014.10.022. Epub 2014 Oct 31. PubMed PMID: 25465154. 4. Iizuka Y, Kuwahara A, Karaki S. Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon. J Physiol Sci. 2014 Mar;64(2):85-96. doi: 10.1007/s12576-013-0295-2. Epub 2013 Oct 30. PubMed PMID: 24170253.