TargetMol

OUP-186

Product Code:
 
TAR-T28275
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28275-5mg5mg£850.00
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TAR-T28275-50mg50mg£1,661.00
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Quantity:
TAR-T28275-100mg100mg£2,079.00
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Further Information

Bioactivity:
OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 μM (R)-(-)-α-methylhistamine (H3R agonist). OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells.
CAS:
1480830-24-7
Formula:
C19H30ClN3S
Molecular Weight:
367.98
Purity:
0.98
SMILES:
Clc1ccc(CCCCNC(=N)SCCCN2CCCCC2)cc1

References

1. Tanaka S, Sakaguchi M, Yoneyama H, Usami Y, Harusawa S. Histamine H(3) receptor antagonist OUP-186 attenuates the proliferation of cultured human breast cancer cell lines. Biochem Biophys Res Commun. 2016 Nov 18;480(3):479-485. doi: 10.1016/j.bbrc.2016.10.077. Epub 2016 Oct 21. PubMed PMID: 27773822. 2. Yoneyama H, Yamamoto D, Yamatodani A, Harusawa S. Efficient Approaches to S-alkyl N-alkylisothioureas and Application to Novel Histamine H3R Antagonists. Yakugaku Zasshi. 2016;136(9):1217-32. doi: 10.1248/yakushi.16-00023. Review. PubMed PMID: 27592826.