TargetMol

Piclozotan (anhydrous)

Product Code:
 
TAR-T28414
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28414-1mg1mg£239.00
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TAR-T28414-5mg5mg£496.00
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TAR-T28414-10mg10mg£713.00
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TAR-T28414-25mg25mg£1,316.00
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TAR-T28414-50mg50mg£1,661.00
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TAR-T28414-100mg100mg£2,079.00
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Further Information

Bioactivity:
Piclozotan (anhydrous), a 5-HT1A receptor agonist, is used potentially for the treatment of Parkinson's disease.
CAS:
182415-09-4
Formula:
C23H24ClN3O2
Molecular Weight:
409.91
Pathway:
GPCR/G Protein|Neuroscience
Purity:
0.98
SMILES:
ClC1=COc2ccccc2C(=O)N1CCCCN1CCC(=CC1)c1ccccn1
Target:
5-HT Receptor

References

1. Tani Y, Ogata A, Koyama M, Inoue T. Effects of piclozotan (SUN N4057), a partial serotonin 1A receptor agonist, on motor complications induced by repeated administration of levodopa in parkinsonian rats. Eur J Pharmacol. 2010 Dec 15;649(1-3):218-23. doi: 10.1016/j.ejphar.2010.09.013. PubMed PMID: 20858480. 2. Mondick JT, Oo C, Patel D, Fujitani T, Shimizu K, Barrett JS. Population pharmacokinetics of the selective serotonin 5-HT1A receptor partial agonist piclozotan. Am J Ther. 2009 Mar-Apr;16(2):106-15. doi: 10.1097/MJT.0b013e31816b8c85. PubMed PMID: 19300037. 3. Kamei K, Maeda N, Nomura K, Shibata M, Katsuragi-Ogino R, Koyama M, Nakajima M, Inoue T, Ohno T, Tatsuoka T. Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan. Bioorg Med Chem. 2006 Mar 15;14(6):1978-92. PubMed PMID: 16290165. 4. Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Dec;31(10):661-700. PubMed PMID: 20140276.