TargetMol

PPZ1

Product Code:
 
TAR-T28444
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28444-5mg5mg£850.00
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TAR-T28444-50mg50mg£1,661.00
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Quantity:
TAR-T28444-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
PPZ1 is a novel DAG-activated TRPC3/TRPC6/TRPC7 channels activator.
CAS:
915893-66-2
Formula:
C18H18ClFN2O
Molecular Weight:
332.8
Purity:
0.98
SMILES:
Cc1ccc(Cl)cc1N1CCN(CC1)C(=O)c1cccc(F)c1

References

1. Molero C, Casado C, Ari?o J. The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis. Sci Rep. 2017 Aug 18;7(1):8819. doi: 10.1038/s41598-017-09360-5. PubMed PMID: 28821821; PubMed Central PMCID: PMC5562863. 2. Chen E, Choy MS, Petr?nyi K, K?nya Z, Erd?di F, Dombr?di V, Peti W, Page R. Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans. MBio. 2016 Aug 30;7(4). pii: e00872-16. doi: 10.1128/mBio.00872-16. PubMed PMID: 27578752; PubMed Central PMCID: PMC4999541. 3. Sawamura S, Hatano M, Takada Y, Hino K, Kawamura T, Tanikawa J, Nakagawa H, Hase H, Nakao A, Hirano M, Rotrattanadumrong R, Kiyonaka S, Mori MX, Nishida M, Hu Y, Inoue R, Nagata R, Mori Y. Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds. Mol Pharmacol. 2016 Mar;89(3):348-63. doi: 10.1124/mol.115.102863. Epub 2016 Jan 5. PubMed PMID: 26733543. 4. Abrie JA, Molero C, Ari?o J, Strauss E. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Sci Rep. 2015 Oct 30;5:15774. doi: 10.1038/srep15774. PubMed PMID: 26514574; PubMed Central PMCID: PMC4626798.