TargetMol

QO-58

Product Code:
 
TAR-T28483
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T28483-100mg100mgEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28483-50mg50mgEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
QO-58 is a Kv7 channel opener with EC50 values of 7.0, 1.0, 5.2, 0.6 μM for Kv7.1, Kv7.2, Kv7.3/7.5, Kv7.4 respectively. QO-58 increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo.
CAS:
1259536-62-3
Formula:
C18H8Cl2F4N4O
Molecular Weight:
443.18
Purity:
0.98
SMILES:
Fc1cc(c(Cl)nc1Cl)-c1cc(=O)n2[nH]c(c(-c3ccccc3)c2n1)C(F)(F)F

References

1. Zhang et al (2013) Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br.J.Pharmacol. 168 1030. PMID: 23013484. 2. Qi et al (2011) Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur.J.Med.Chem. 46 934. PMID: 21296466.