TargetMol

R-(-)-Niguldipine hydrochloride

Product Code:
 
TAR-T28489
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T28489-5mg5mg£850.00
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Further Information

Bioactivity:
R-(-)-Niguldipine hydrochloride is a L-type Ca2+ channel blocker; potassium agonist that activates Ca2+-activated maxi K-channel; alpha1A-adrenoceptor antagonist; antihypertensive agent; Less active enantiomer.
CAS:
113145-70-3
Formula:
C36H40ClN3O6
Molecular Weight:
646.18
Purity:
0.98
SMILES:
Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1

References

1. Zhou XF, Yang X, Wang Q, Coburn RA, Morris ME. Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein: in vitro and in vivo studies. Drug Metab Dispos. 2005 Aug;33(8):1220-8. Epub 2005 May 20. PubMed PMID: 15908473. 2. Honner V, Docherty JR. Investigation of the subtypes of alpha1-adrenoceptor mediating contractions of rat vas deferens. Br J Pharmacol. 1999 Nov;128(6):1323-31. PubMed PMID: 10578148; PubMed Central PMCID: PMC1571755. 3. Macleod RJ, Lembessis P, James S, Bennett HP. Isolation of a member of the neurotoxin/cytotoxin peptide family from Xenopus laevis skin which activates dihydropyridine-sensitive Ca2+ channels in mammalian epithelial cells. J Biol Chem. 1998 Aug 7;273(32):20046-51. PubMed PMID: 9685343. 4. Taniguchi N, Ukai Y, Tanaka T, Yano J, Kimura K, Moriyama N, Kawabe K. Identification of alpha 1-adrenoceptor subtypes in the human prostatic urethra. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):412-6. PubMed PMID: 9089674.