TargetMol

R-84760 hydrochloride

Product Code:
 
TAR-T28495
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28495-5mg5mg£1,010.00
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TAR-T28495-50mg50mg£1,982.00
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TAR-T28495-100mg100mg£2,560.00
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Further Information

Bioactivity:
R-84760 is a κ-opioid receptor agonist. R-84760 produces an extremely potent antinociceptive effect against tonic pain through the kappa-opioid receptors; the sites of action of subcutaneously administered R-84760 are the supraspinal and spinal loci in the central nervous system; and a part of the mechanism of the antinociceptive effect of R-84760 is activation of the descending noradrenergic pathway.
CAS:
157824-23-2
Formula:
C19H25Cl3N2OS
Molecular Weight:
435.83
Purity:
0.98
SMILES:
Cl.Clc1cc2CC[C@H](C(=O)N3CCSC[C@H]3CN3CCCC3)c2cc1Cl

References

1. Ohsawa M, Kamei J. Modification of kappa-opioid receptor agonist-induced antinociception by diabetes in the mouse brain and spinal cord. J Pharmacol Sci. 2005 May;98(1):25-32. PubMed PMID: 15879680. 2. Mori T, Nomura M, Yoshizawa K, Nagase H, Narita M, Suzuki T. Differential properties between TRK-820 and U-50,488H on the discriminative stimulus effects in rats. Life Sci. 2004 Oct 1;75(20):2473-82. PubMed PMID: 15350822. 3. Zhang Y, Butelman ER, Schlussman SD, Ho A, Kreek MJ. Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology (Berl). 2004 Apr;173(1-2):146-52. PubMed PMID: 14712342. 4. Kobayashi N, Kazui M, Ikeda T. Rapid, real-time sampling of R-84760 in blood by in vivo microdialysis with tandem mass spectrometry. J Pharm Biomed Anal. 2000 Jan;21(6):1233-42. PubMed PMID: 10708407.