TargetMol

RK-9123016

Product Code:
 
TAR-T28543
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28543-5mg5mg£111.00
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Quantity:
TAR-T28543-1mL1 mL * 10 mM (in DMSO)£124.00
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Quantity:
TAR-T28543-10mg10mg£131.00
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Quantity:
TAR-T28543-25mg25mg£173.00
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Quantity:
TAR-T28543-50mg50mg£225.00
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Quantity:
TAR-T28543-100mg100mg£301.00
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Quantity:
TAR-T28543-200mg200mg£417.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.
CAS:
955900-27-3
Formula:
C16H18N6O3S
Molecular Weight:
374.42
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.98
SMILES:
COc1ccc(C=NNC(=S)NCC=C)cc1Cn1cc(cn1)[N+]([O-])=O
Target:
Sirtuin

References

1. Shah AA, Ito A, Nakata A, Yoshida M. Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity. Biol Pharm Bull. 2016;39(10):1739-1742. PubMed PMID: 27725455.