TargetMol

RX-37

Product Code:
 
TAR-T28630
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28630-5mg5mg£1,251.00
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Quantity:
TAR-T28630-50mg50mg£2,464.00
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Quantity:
TAR-T28630-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
RX-37 is a potent BET inhibitor with Ki values of 3.2-24.7 nM for BRD2, BRD3 and BRD4. RX-37 demonstrates high selectivity over other non-BET bromodomain-containing proteins. RX-37 potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged mixed lineage leukemia 1 gene.
CAS:
1627715-60-9
Formula:
C24H23N5O2
Molecular Weight:
413.481
Purity:
0.98
SMILES:
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21

References

1. Ran X, Zhao Y, Liu L, Bai L, Yang CY, Zhou B, Meagher JL, Chinnaswamy K, Stuckey JA, Wang S. Structure-Based Design of ?-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J Med Chem. 2015 Jun 25;58(12):4927-39. doi: 10.1021/acs.jmedchem.5b00613. Epub 2015 Jun 16. PubMed PMID: 26080064.