TargetMol

S33084

Product Code:
 
TAR-T28647
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28647-5mg5mg£1,251.00
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TAR-T28647-50mg50mg£2,464.00
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Quantity:
TAR-T28647-100mg100mg£3,283.00
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  • Further Information
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Further Information

Bioactivity:
S33084 is a potent, selective and competitive antagonist of dopamine D(3)-receptors.
CAS:
273203-30-8
Formula:
C29H29N3O2
Molecular Weight:
451.57
Purity:
0.98
SMILES:
[H][C@]12CN(CCCCNC(=O)c3ccc(cc3)-c3ccccc3)C[C@]1([H])c1cc(ccc1OC2)C#N

References

1. Mela F, Millan MJ, Brocco M, Morari M. The selective D(3) receptor antagonist, S33084, improves parkinsonian-like motor dysfunction but does not affect L-DOPA-induced dyskinesia in 6-hydroxydopamine hemi-lesioned rats. Neuropharmacology. 2010 Feb;58(2):528-36. doi: 10.1016/j.neuropharm.2009.08.017. Epub 2009 Sep 4. PubMed PMID: 19733554. 2. Millan MJ, Dekeyne A, Rivet JM, Dubuffet T, Lavielle G, Brocco M. S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther. 2000 Jun;293(3):1063-73. PubMed PMID: 10869411. 3. Millan MJ, Gobert A, Newman-Tancredi A, Lejeune F, Cussac D, Rivet JM, Audinot V, Dubuffet T, Lavielle G. S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther. 2000 Jun;293(3):1048-62. PubMed PMID: 10869410. 4. Cussac D, Newman-Tancredi A, Sezgin L, Millan MJ. [3H]S33084: a novel, selective and potent radioligand at cloned, human dopamine D3 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2000 May;361(5):569-72. PubMed PMID: 10832613.