TargetMol

Sabiporide

Product Code:
 
TAR-T28656
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28656-5mg5mg£850.00
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TAR-T28656-50mg50mg£1,661.00
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Quantity:
TAR-T28656-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Sabiporide is a NHE-1 inhibitor and a cardioprotective agent.
CAS:
324758-66-9
Formula:
C18H19F3N6O2
Molecular Weight:
408.385
Purity:
0.98
SMILES:
NC(=N)NC(=O)c1ccc(N2CCN(CC2)C(=O)c2ccc[nH]2)c(c1)C(F)(F)F

References

1. Doods H, Wu D. Sabiporide reduces ischemia-induced arrhythmias and myocardial infarction and attenuates ERK phosphorylation and iNOS induction in rats. Biomed Res Int. 2013;2013:504320. doi: 10.1155/2013/504320. Epub 2012 Dec 30. PubMed PMID: 23484128; PubMed Central PMCID: PMC3591136. 2. Lin X, Kraut JA, Wu D. Coadministration of a Na+-H+ exchange inhibitor and sodium bicarbonate for the treatment of asphyxia-induced cardiac arrest in piglets. Pediatr Res. 2014 Aug;76(2):118-26. doi: 10.1038/pr.2014.65. Epub 2014 May 5. PubMed PMID: 24796369. 3. Park SL, Lee DH, Yoo SE, Jung YS. The effect of Na(+)/H(+) exchanger-1 inhibition by sabiporide on blood-brain barrier dysfunction after ischemia/hypoxia in vivo and in vitro. Brain Res. 2010 Dec 17;1366:189-96. doi: 10.1016/j.brainres.2010.09.077. Epub 2010 Sep 29. PubMed PMID: 20883671. 4. Lin X, Lee D, Wu D. Sabiporide improves cardiovascular function and attenuates organ injury from severe sepsis. J Surg Res. 2014 May 1;188(1):231-7. doi: 10.1016/j.jss.2013.12.001. Epub 2013 Dec 12. PubMed PMID: 24411641.