TargetMol

SAR-114137

Product Code:
 
TAR-T28658
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28658-5mg5mg£1,251.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28658-50mg50mg£2,464.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28658-100mg100mg£3,283.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
SAR-114137 is an inhibitor of cysteine cathepsin with oral activity.
CAS:
537706-31-3
Formula:
C25H34N4O7S
Molecular Weight:
534.63
Purity:
0.98
SMILES:
CC[C@H](NC(=O)C(CC(=O)N1CCOCC1)CS(=O)(=O)CC(C)C)C(=O)c1noc(n1)-c1ccccc1

References

1. Petzoldt C, Bley O, Byard SJ, Andert D, Baumgartner B, Nagel N, Tappertzhofen C, Feth MP. An example of how to handle amorphous fractions in API during early pharmaceutical development: SAR114137--a successful approach. Eur J Pharm Biopharm. 2014 Apr;86(3):337-50. doi: 10.1016/j.ejpb.2013.09.015. PubMed PMID: 24075979. 2. Feth MP, Heyse W, Baumgartner B, Nagel N, Tappertzhofen C, Olpp T, Jurascheck J, Ulrich J, Helmdach L, Petzoldt C. From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48. doi: 10.1016/j.ejpb.2012.11.007. PubMed PMID: 23201054.