SKI2852

Product Code:

TAR-T28796

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T28796-25mg

25mg

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Further Information

Bioactivity:

SKI2852 is a highly Potent, selective, and orally bioavailable inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). hHSD1 IC50 = 2.9nM; mHSD1 IC50 = 1.6nM.

CAS:

1346554-47-9

Formula:

C27H34FN5O4S

Molecular Weight:

543.66

Purity:

0.98

SMILES:

C[C@@H]1CN(CCN1c1nccc(n1)C(=O)N[C@H]1[C@H]2C[C@H]3C[C@@H]1C[C@](O)(C3)C2)c1ccc(cc1F)S(C)(=O)=O

Documents

References

1. Ryu JH, Lee JA, Kim S, Shin YA, Yang J, Han HY, Son HJ, Kim YH, Sa JH, Kim JS, Lee J, Lee J, Park HG. Discovery of 2-((R)-4-(2-Fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)-N-((1R,2s,3S ,5S,7S)-5-hydroxyadamantan-2-yl)pyrimidine-4-carboxamide (SKI2852): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of 11?-Hydroxysteroid Dehydrogenase Type 1 (11?-HSD1). J Med Chem. 2016 Oct 31. [Epub ahead of print] PubMed PMID: 27798827. 2. Oh H, Jeong KH, Han HY, Son HJ, Kim SS, Lee HJ, Kim S, Sa JH, Jun HS, Ryu JH, Choi CS. A potent and selective 11?-hydroxysteroid dehydrogenase type 1 inhibitor, SKI2852, ameliorates metabolic syndrome in diabetic mice models. Eur J Pharmacol. 2015 Dec 5;768:139-48. doi: 10.1016/j.ejphar.2015.10.042. PubMed PMID: 26519792.