TargetMol

SSR504734

Product Code:
 
TAR-T28858
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28858-5mg5mg£470.00
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TAR-T28858-50mg50mg£2,303.00
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Quantity:
TAR-T28858-100mg100mg£3,042.00
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Further Information

Bioactivity:
SSR504734 is a novel potent glycine transporter 1 (GlyT1) inhibitor.
CAS:
742693-38-5
Formula:
C20H20ClF3N2O
Molecular Weight:
396.84
Purity:
0.98
SMILES:
FC(F)(F)c1cccc(C(=O)NC[C@@H]2CCCCN2c2ccccc2)c1Cl

References

1. Yamamoto S, Shibata T, Abe K, Oda K, Aoki T, Kawakita Y, Kawamoto H. Discovery of 3-Chloro-N-{(S)-[3-(1-ethyl-1H-pyrazol-4-yl)phenyl][(2S)-piperidine-2-yl]methyl}- 4-(trifluoromethyl)pyridine-2-carboxamide as a Potent Glycine Transporter 1 Inhibitor. Chem Pharm Bull (Tokyo). 2016;64(9):1321-37. doi: 10.1248/cpb.c16-00314. PubMed PMID: 27581637. 2. Komatsu H, Furuya Y, Sawada K, Asada T. Involvement of the strychnine-sensitive glycine receptor in the anxiolytic effects of GlyT1 inhibitors on maternal separation-induced ultrasonic vocalization in rat pups. Eur J Pharmacol. 2015 Jan 5;746:252-7. doi: 10.1016/j.ejphar.2014.11.024. Epub 2014 Nov 27. PubMed PMID: 25435080. 3. Singer P, Zhang W, Yee BK. SSR504734 enhances basal expression of prepulse inhibition but exacerbates the disruption of prepulse inhibition by apomorphine. Psychopharmacology (Berl). 2013 Nov;230(2):309-17. doi: 10.1007/s00213-013-3160-3. Epub 2013 Jun 5. PubMed PMID: 23736281; PubMed Central PMCID: PMC3809335. 4. Cervo L, Di Clemente A, Orr? A, Moro F, Cassina C, Pich EM, Corsi M, Gozzi A, Bifone A. Inhibition of glycine transporter-1 reduces cue-induced nicotine-seeking, but does not promote extinction of conditioned nicotine cue responding in the rat. Addict Biol. 2013 Sep;18(5):800-11. doi: 10.1111/adb.12049. Epub 2013 Mar 14. PubMed PMID: 23490434.