TargetMol

SUN-C5174

Product Code:
 
TAR-T28884
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28884-5mg5mg£850.00
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TAR-T28884-50mg50mg£1,661.00
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Quantity:
TAR-T28884-100mg100mg£2,079.00
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Further Information

Bioactivity:
SUN-C5174 is a sleective 5-HT2 antagonist (pA2=8.98+/-0.06). SUN C5174 showed a marked inhibitory effect on the platelet aggregation induced by serotonin in combination with collagen and adenosine diphosphate (ADP) in canine or human platelet-rich plasma (IC50=6.5 to 16 nM). SUN-C5174 significantly inhibited the mortality rate in mouse acute pulmonary thromboembolytic death induced by collagen and serotonin at oral doses of 0.3 mg/kg or higher.
CAS:
191592-36-6
Formula:
C22H29FN4O2
Molecular Weight:
400.498
Purity:
0.98
SMILES:
Cn1ccc2c1[C@@H](O)CCN(CCCN1CCN(CC1)c1ccc(F)cc1)C2=O

References

1. Mizuno A, Ogata A, Kamei T, Shibata M, Shimamoto T, Hayashi Y, Nakanishi K, Takiguchi C, Oka N, Inomata N. Synthesis and serotonin 2 (5-HT2) receptor antagonist activity of 5-aminoalkyl-substituted pyrrolo[3,2-c]azepines and related compounds. Chem Pharm Bull (Tokyo). 2000 May;48(5):623-35. PubMed PMID: 10823697.