TargetMol

SX-517

Product Code:
 
TAR-T28893
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28893-5mg5mg£293.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T28893-50mg50mg£1,267.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28893-100mg100mg£1,974.00
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This product comes from: United States.
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Further Information

Bioactivity:
SX-517 is a potent noncompetitive boronic acid CXCR1/2 antagonist. SX-517 inhibits CXCL1-induced Ca(2+) flux (IC50 = 38 nM) in human PMNs.
CAS:
1240494-13-6
Formula:
C19H16BFN2O3S
Molecular Weight:
382.22
Purity:
0.98
SMILES:
OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1

References

1. Schuler AD, Engles CA, Maeda DY, Quinn MT, Kirpotina LN, Wicomb WN, Mason SN, Auten RL, Zebala JA. Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3793-7. doi: 10.1016/j.bmcl.2015.07.090. Epub 2015 Jul 30. PubMed PMID: 26248802; PubMed Central PMCID: PMC4564001. 2. Maeda DY, Peck AM, Schuler AD, Quinn MT, Kirpotina LN, Wicomb WN, Fan GH, Zebala JA. Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2. J Med Chem. 2014 Oct 23;57(20):8378-97. doi: 10.1021/jm500827t. Epub 2014 Oct 8. PubMed PMID: 25254640; PubMed Central PMCID: PMC4207547.