TargetMol

VE-465

Product Code:
 
TAR-T29101
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29101-5mg5mg£850.00
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Further Information

Bioactivity:
VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.
CAS:
639089-73-9
Formula:
C22H28N8OS
Molecular Weight:
452.58
Purity:
0.98
SMILES:
CCC(=O)Nc1ccc(Sc2nc(Nc3cc(C)[nH]n3)cc(n2)N2CCN(C)CC2)cc1

References

1. Falchook GS, Bastida CC, Kurzrock R. Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress. Semin Oncol. 2015 Dec;42(6):832-48. doi: 10.1053/j.seminoncol.2015.09.022. Epub 2015 Sep 24. Review. PubMed PMID: 26615129. 2. Cooper S, Giles FJ, Savona MR. Overcoming resistance in chronic myelogenous leukemia. Leuk Lymphoma. 2009 Nov;50(11):1785-93. doi: 10.3109/10428190903267559. Review. PubMed PMID: 19883308. 3. Liang YQ, Chen BA, Chen YL. [Research progress on aurora kinase inhibitor MK-0457 in therapy for some hematological malignancies -- review]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Jun;17(3):810-5. Review. Chinese. PubMed PMID: 19549414. 4. Chen XG, Zhang Y. [Recent advance in the study of novel anti-tumor targets and drugs--aurora kinase and Pin1]. Yao Xue Xue Bao. 2009 Mar;44(3):264-9. Review. Chinese. PubMed PMID: 19449522.