TargetMol

VRT-532

Product Code:
 
TAR-T29114
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T29114-1mg1mg£335.00
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Quantity:
TAR-T29114-1mL1 mL * 10 mM (in DMSO)£711.00
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Quantity:
TAR-T29114-5mg5mg£711.00
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TAR-T29114-10mg10mg£946.00
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Quantity:
TAR-T29114-25mg25mg£1,396.00
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Quantity:
TAR-T29114-50mg50mg£1,862.00
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Quantity:
TAR-T29114-100mg100mg£2,424.00
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Quantity:
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
VRT-532 is a CFTR modulator used to treat cystic fibrosis.
CAS:
38214-71-0
Formula:
C16H14N2O
Molecular Weight:
250.301
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
Cc1ccc(O)c(c1)-c1cc([nH]n1)-c1ccccc1
Target:
CFTR

References

1. Bhattacharyya S, Feferman L, Tobacman JK. Effect of CFTR modifiers on arylsulfatase B activity in cystic fibrosis and normal human bronchial epithelial cells. Pulm Pharmacol Ther. 2016 Feb;36:22-30. doi: 10.1016/j.pupt.2015.11.005. Epub 2015 Nov 30. PubMed PMID: 26656789. 2. Ni I, Ji C, Vij N. Second-hand cigarette smoke impairs bacterial phagocytosis in macrophages by modulating CFTR dependent lipid-rafts. PLoS One. 2015 Mar 20;10(3):e0121200. doi: 10.1371/journal.pone.0121200. eCollection 2015. PubMed PMID: 25794013; PubMed Central PMCID: PMC4368805. 3. Pettit RS, Fellner C. CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 Jul;39(7):500-11. PubMed PMID: 25083129; PubMed Central PMCID: PMC4103577. 4. Conger BT, Zhang S, Skinner D, Hicks SB, Sorscher EJ, Rowe SM, Woodworth BA. Comparison of cystic fibrosis transmembrane conductance regulator (CFTR) and ciliary beat frequency activation by the CFTR Modulators Genistein, VRT-532, and UCCF-152 in primary sinonasal epithelial cultures. JAMA Otolaryngol Head Neck Surg. 2013 Aug 1;139(8):822-7. doi: 10.1001/jamaoto.2013.3917. Erratum in: JAMA Otolaryngol Head Neck Surg. 2013 Oct;139(10):1. PubMed PMID: 23949358; PubMed Central PMCID: PMC3933974.