TargetMol

VU 0469650 hydrochloride

Product Code:
 
TAR-T29118
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29118-1mg1mg£119.00
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TAR-T29118-5mg5mg£187.00
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TAR-T29118-1mL1 mL * 10 mM (in DMSO)£199.00
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TAR-T29118-10mg10mg£242.00
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TAR-T29118-25mg25mg£431.00
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TAR-T29118-50mg50mg£600.00
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TAR-T29118-100mg100mg£825.00
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TAR-T29118-500mg500mg£1,581.00
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Further Information

Bioactivity:
VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM).
CAS:
1443748-47-7
Formula:
C22H29ClN4O
Molecular Weight:
400.95
Pathway:
Neuroscience
Purity:
0.98
SMILES:
Cl.C[C@@H]1CN(CCN1C(=O)C12CC3CC(CC(C3)C1)C2)c1cccnc1C#N
Target:
GluR

References

1. Lovell KM, Felts AS, Rodriguez AL, Venable DF, Cho HP, Morrison RD, Byers FW, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA. N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3713-8. doi: 10.1016/j.bmcl.2013.05.020. Epub 2013 May 17. PubMed PMID: 23727046; PubMed Central PMCID: PMC3875306.