TargetMol

YM-430

Product Code:
 
TAR-T29183
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29183-5mg5mg£850.00
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TAR-T29183-50mg50mg£1,661.00
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TAR-T29183-100mg100mg£2,079.00
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Further Information

Bioactivity:
YM-430 is a β1 adrenergic receptor antagonist and a calcium channel antagonist. YM430 could be both an antianginal and antihypertensive agent. YM430 (10(-8)-10(-6) M) inhibited 3,4-diaminopyridine-induced rhythmic contractions with an IC50 value of 59.2 nM. In anesthetized rats, YM430 (10-100 mg/kg PO) inhibited arginine vasopressin-induced ST-segment depression with an IC50 value of 36.6 mg/kg PO.
CAS:
153192-22-4
Formula:
C29H35N3O8
Molecular Weight:
553.612
Purity:
0.98
SMILES:
COC(=O)C1=C(C)NC(C)=C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCCNC[C@H](O)COc1ccccc1

References

1. Sasaki S, Nakagawa M. [Calcium channel blocker for therapy of patients with hypertension]. Nihon Rinsho. 1997 Aug;55(8):2061-6. Review. Japanese. PubMed PMID: 9284424. 2. Shibasaki K, Arai Y, Uchida W, Okazaki T, Asano M, Takenaka T. Antianginal effects of YM430, a novel calcium entry-blocking and beta-adrenoceptor-blocking agent in several experimental angina models. Gen Pharmacol. 1997 Oct;29(4):545-50. PubMed PMID: 9352300. 3. Shibasaki K, Uchida W, Takizawa K, Masuda N, Okazaki T, Inagaki O, Asano M, Takenaka T. Cardiovascular effects of YM430, a 1,4-dihydropyridine derivative with beta-adrenoceptor blocking activity, in dogs and rats. Biol Pharm Bull. 1997 Mar;20(3):230-6. PubMed PMID: 9084878. 4. Shibasaki K, Takizawa K, Uchida W, Takenaka T. Hypotensive effects of YM430, a 1,4-dihydropyridine derivative, in spontaneously hypertensive rats and renal hypertensive dogs. Jpn J Pharmacol. 1997 Feb;73(2):113-24. PubMed PMID: 9074945.