TargetMol

YM49598

Product Code:
 
TAR-T29186
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29186-5mg5mg£1,010.00
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TAR-T29186-50mg50mg£1,982.00
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TAR-T29186-100mg100mg£2,560.00
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Further Information

Bioactivity:
YM49598 is a tachykinin receptor antagonist. YM49598 exhibited high binding affinities at NK(1) (pK(i) = 9.09 +/- 0.02) and NK(2) (pK(i) = 9.94 +/- 0.03) receptors, respectively. YM49598 was almost inactive but produced a potent inhibition (IC(50) = 11 +/- 7 microg x kg(-1)) of the contraction of the rat urinary bladder induced by challenge with the NK(1)-selective receptor agonist [Sar9,Met(O(2))11]substance P sulphone (0.3 microg x kg(-1)).
CAS:
738575-62-7
Formula:
C36H45Cl2N2O2
Molecular Weight:
608.67
Purity:
0.98
SMILES:
CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC(CC3)c3ccccc3)(C2)c2ccc(Cl)c(Cl)c2)c1

References

1. Choppin A, Groke G, Bringas A, Stepan G, Dillon MP. Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002 May;65(2):96-102. PubMed PMID: 11937780.