TargetMol

ZD4190 HCl

Product Code:
 
TAR-T29209
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29209-5mg5mg£850.00
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TAR-T29209-50mg50mg£1,661.00
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Quantity:
TAR-T29209-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
ZD-4190, a potent VEGFR inhibitor, prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues.
CAS:
257938-36-6
Formula:
C19H17BrClFN6O2
Molecular Weight:
495.74
Purity:
0.98
SMILES:
Cl.COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCn1ccnn1

References

1. Yang M, Gao H, Yan Y, Sun X, Chen K, Quan Q, Lang L, Kiesewetter D, Niu G, Chen X. PET imaging of early response to the tyrosine kinase inhibitor ZD4190. Eur J Nucl Med Mol Imaging. 2011 Jul;38(7):1237-47. doi: 10.1007/s00259-011-1742-z. PubMed PMID: 21360246; PubMed Central PMCID: PMC3184245. 2. Gaballah K, Oakley R, Hills A, Ryan A, Partridge M. The antiangiogenic agent ZD4190 prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues. Br J Cancer. 2009 Aug 4;101(3):418-23. doi: 10.1038/sj.bjc.6605092. PubMed PMID: 19623179; PubMed Central PMCID: PMC2720249. 3. Nguyen QD, Rodrigues S, Rodrigue CM, Rivat C, Grijelmo C, Bruyneel E, Emami S, Attoub S, Gespach C. Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts. Mol Cancer Ther. 2006 Aug;5(8):2070-7. PubMed PMID: 16928828. 4. Checkley D, Tessier JJ, Wedge SR, Dukes M, Kendrew J, Curry B, Middleton B, Waterton JC. Dynamic contrast-enhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenografts. Magn Reson Imaging. 2003 Jun;21(5):475-82. PubMed PMID: 12878256.