TargetMol

ZK93423

Product Code:
 
TAR-T29228
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29228-5mg5mg£850.00
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TAR-T29228-50mg50mg£1,661.00
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Quantity:
TAR-T29228-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
ZK93423 is a potent agonist of benzodiazepine receptor (IC50 = 1 nM) with non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors, Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors respectively.
CAS:
83910-44-5
Formula:
C23H22N2O4
Molecular Weight:
390.439
Purity:
0.98
SMILES:
CCOC(=O)c1ncc2[nH]c3ccc(OCc4ccccc4)cc3c2c1COC

References

1. Ferretti V, Gilli P, Borea PA. Structural features controlling the binding of beta-carbolines to the benzodiazepine receptor. Acta Crystallogr B. 2004 Aug;60(Pt 4):481-9. Epub 2004 Jul 19. PubMed PMID: 15258407. 2. Zhang H, Larock RC. Synthesis of beta- and gamma-carbolines by the palladium-catalyzed iminoannulation of alkynes. J Org Chem. 2002 Dec 27;67(26):9318-30. PubMed PMID: 12492334. 3. Davies M, Bateson AN, Dunn SM. Structural requirements for ligand interactions at the benzodiazepine recognition site of the GABA(A) receptor. J Neurochem. 1998 May;70(5):2188-94. PubMed PMID: 9572307. 4. Rodgers RJ, Randall JI. Are the analgesic effects of social defeat mediated by benzodiazepine receptors? Physiol Behav. 1987;41(3):279-89. PubMed PMID: 2829247.