TargetMol

Abediterol

Product Code:
 
TAR-T29518
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29518-5mg5mg£1,010.00
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TAR-T29518-50mg50mg£1,982.00
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TAR-T29518-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
Abediterol (LAS100977) is a new potent, long-acting inhaled beta (2) -adrenergic receptor agonist being developed for the treatment of asthma and chronic obstructive pulmonary disease.
CAS:
915133-65-2
Formula:
C25H30F2N2O4
Molecular Weight:
460.522
Purity:
0.98
SMILES:
O[C@@H](CNCCCCCCOCC(F)(F)c1ccccc1)c1ccc(O)c2[nH]c(=O)ccc12

References

1. Aparici M, Gavald? A, Ramos I, Carcasona C, Otal R, Fern?ndez-Blanco JA, Montero JL, Garc?a VM, L?pez R, De Alba J, Doe C, Puig C, Vilella D, Miralpeix M. In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting ?2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol. Eur J Pharmacol. 2016 Jan 5;770:61-9. doi: 10.1016/j.ejphar.2015.11.053. Epub 2015 Dec 4. PubMed PMID: 26656755. 2. Montuschi P, Ciabattoni G. Bronchodilating drugs for chronic obstructive pulmonary disease: current status and future trends. J Med Chem. 2015 May 28;58(10):4131-64. doi: 10.1021/jm5013227. Epub 2015 Feb 9. PubMed PMID: 25587755. 3. Singh D, Pujol H, Ribera A, Seoane B, Massana E, Astbury C, Ruiz S, de Miquel G. A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting ?2-adrenergic agonist, in asthma; a Phase II, randomized study. BMC Pulm Med. 2014 Nov 14;14:176. doi: 10.1186/1471-2466-14-176. PubMed PMID: 25398689; PubMed Central PMCID: PMC4320624. 4. Beier J, Fuhr R, Massana E, Jim?nez E, Seoane B, de Miquel G, Ruiz S. Abediterol (LAS100977), a novel long-acting ?2-agonist: efficacy, safety and tolerability in persistent asthma. Respir Med. 2014 Oct;108(10):1424-9. doi: 10.1016/j.rmed.2014.08.005. Epub 2014 Sep 8. PubMed PMID: 25256258.