TargetMol

AC-119

Product Code:
 
TAR-T29538
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29538-5mg5mg£850.00
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Quantity:
TAR-T29538-50mg50mg£1,661.00
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Quantity:
TAR-T29538-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
AC-119 is a bamifylline metabolite in human plasma. It has been shown to induce apoptosis in cancer cells while having no effect on health cells in humans.
CAS:
80296-67-9
Formula:
C18H23N5O2
Molecular Weight:
341.415
Purity:
0.98
SMILES:
CCNCCn1c(Cc2ccccc2)nc2n(C)c(=O)n(C)c(=O)c12

References

1. Schiantarelli P, Acerbi D, Botta GC, Bonati L, Capelli P, Rondelli I. Evidence of pulmonary tropism of bamifylline and its main active metabolite. Arzneimittelforschung. 1989 Feb;39(2):215-9. PubMed PMID: 2730690. 2. Ohkawa T, Washburn JO, Sitapara R, Sid E, Volkman LE. Specific binding of Autographa californica M nucleopolyhedrovirus occlusion-derived virus to midgut cells of Heliothis virescens larvae is mediated by products of pif genes Ac119 and Ac022 but not by Ac115. J Virol. 2005 Dec;79(24):15258-64. PubMed PMID: 16306597; PubMed Central PMCID: PMC1316039. 3. Segre G, Cerretani D, Moltoni L, Urso R, Fusillo M. Pharmacokinetics of bamifylline during chronic therapy. Arzneimittelforschung. 1990 Apr;40(4):450-2. PubMed PMID: 2357245. 4. Jesus Barreto de Melo R?go M, Layssa Batista de Sena W, de Moura RO, Ten?rio Jacob IT, Lins E Lins TU, Pereia MC, Carmo Alves de Lima MD, Galdino-Pitta MR, Rocha Pitta ID, da Rocha Pitta MG. Synthesis and Anticancer Evaluation of Thiazacridine Derivatives Reveals New Selective Molecules to Hematopoietic Neoplastic Cells. Comb Chem High Throughput Screen. 2017 Jul 24. doi: 10.2174/1386207320666170724114802. [Epub ahead of print] PubMed PMID: 28738767.