TargetMol

AFB1-N7-guanine

Product Code:
 
TAR-T29689
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29689-5mg5mg£850.00
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Further Information

Bioactivity:
In epidemiological studies, Aflatoxin B1-N7-guanine serum albumin adducts have been established as biomarkers of dietary aflatoxin exposure.
CAS:
79982-94-8
Formula:
C22H17N5O8
Molecular Weight:
479.405
Purity:
0.98
SMILES:
[H][C@]12O[C@H]([C@H](O)[C@@]1([H])c1c(O2)cc(OC)c2c3CCC(=O)c3c(=O)oc12)n1cnc2c1nc(N)[nH]c2=O

References

1. Sriwattanapong K, Slocum SL, Chawanthayatham S, Fedeles BI, Egner PA, Groopman JD, Satayavivad J, Croy RG, Essigmann JM. Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver. Toxicol Sci. 2017 Nov 1;160(1):173-179. doi: 10.1093/toxsci/kfx171. PubMed PMID: 28973694; PubMed Central PMCID: PMC5837592. 2. Mupunga I, Izaaks CD, Shai LJ, Katerere DR. Aflatoxin biomarkers in hair may facilitate long-term exposure studies. J Appl Toxicol. 2017 Apr;37(4):395-399. doi: 10.1002/jat.3422. Epub 2016 Dec 9. Review. PubMed PMID: 27933645. 3. Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M. Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Toxicol Sci. 2016 Jul;152(1):40-52. doi: 10.1093/toxsci/kfw065. Epub 2016 Apr 12. PubMed PMID: 27071940; PubMed Central PMCID: PMC4922541. 4. Reddy L, Odhav B, Bhoola K. Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage. Biol Chem. 2006 Jan;387(1):87-93. PubMed PMID: 16497168.