TargetMol

AMG-369

Product Code:
 
TAR-T29971
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29971-5mg5mg£1,091.00
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TAR-T29971-50mg50mg£2,143.00
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Quantity:
TAR-T29971-100mg100mg£2,801.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
AMG-369 (KB74649) is an effective S1P1/S1P5 dual agonist, with limited activity in S1P3, but no activity in S1P2/S1P4.
CAS:
1202073-26-4
Formula:
C26H22FN3O2S
Molecular Weight:
459.54
Purity:
0.98
SMILES:
OC(=O)C1CN(Cc2ccc(-c3nc4cc(cnc4s3)C3(CC3)c3ccccc3)c(F)c2)C1

References

1. Victor J. Cee*?, Mike Frohn?, Brian A. Lanman?, Jennifer Golden?, Kristine Muller?, Susana Neira?, Alex Pickrell?, Heather Arnett?, Janet Buys?, Anu Gore?, Mike Fiorino?, Michelle Horner?, Andrea Itano?, Matt R. Lee?, Michele McElvain?, Scot Middleton?, Michael Schrag?, Dalia Rivenzon-Segal?, Hugo M. Vargas?, Han Xu?, Yang Xu?, Xuxia Zhang?, Jerry Siu?, Min Wong?, and Roland W. B?rli. Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5. ACS Med. Chem. Lett., 2011, 2 (2), pp 107?112