TargetMol

Atagabalin

Product Code:
 
TAR-T30188
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T30188-5mg5mg£850.00
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TAR-T30188-50mg50mg£1,661.00
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Quantity:
TAR-T30188-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Atagabalin, also known as PD 0200390, is a gabamimetic agent under development for the treatment for insomnia. Atagabalin is related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2). It was discontinued following unsatisfactory trial results.
CAS:
223445-75-8
Formula:
C10H19NO2
Molecular Weight:
185.267
Purity:
0.98
SMILES:
C[C@H]1CC(CN)(CC(O)=O)C[C@@H]1C

References

1. Kjellsson MC, Ouellet D, Corrigan B, Karlsson MO. Modeling sleep data for a new drug in development using markov mixed-effects models. Pharm Res. 2011 Oct;28(10):2610-27. doi: 10.1007/s11095-011-0490-x. Epub 2011 Jun 17. PubMed PMID: 21681607. 2. Corrigan B, Feltner DE, Ouellet D, Werth JL, Moton AE, Gibson G. Effect of renal impairment on the pharmacokinetics of PD 0200390, a novel ligand for the voltage-gated calcium channel alpha-2-delta subunit. Br J Clin Pharmacol. 2009 Aug;68(2):174-80. doi: 10.1111/j.1365-2125.2009.03444.x. PubMed PMID: 19694735; PubMed Central PMCID: PMC2767279.