TargetMol

AZ12441970

Product Code:
 
TAR-T30245
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T30245-5mg5mg£1,492.00
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Quantity:
TAR-T30245-50mg50mg£2,946.00
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Quantity:
TAR-T30245-100mg100mg£4,006.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
AZ12441970 is an effective agonist of Toll-like receptor 7 (TLR7 agonist).
CAS:
929551-91-7
Formula:
C27H41N7O4
Molecular Weight:
527.67
Purity:
0.98
SMILES:
CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(CCCN(C)C)Cc3cccc(CC(=O)OC)c3)c2n1

References

1. Edwards S, Jones C, Leishman AJ, Young BW, Matsui H, Tomizawa H, Murray CM, Biffen M. TLR7 stimulation of APCs results in inhibition of IL-5 through type I IFN and Notch signaling pathways in human peripheral blood mononuclear cells. J Immunol. 2013 Mar 15;190(6):2585-92. doi: 10.4049/jimmunol.1200780. Epub 2013 Feb 4. PubMed PMID: 23382558. 2. Biffen M, Matsui H, Edwards S, Leishman AJ, Eiho K, Holness E, Satterthwaite G, Doyle I, Wada H, Fraser NJ, Hawkins SL, Aoki M, Tomizawa H, Benjamin AD, Takaku H, McInally T, Murray CM. Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br J Pharmacol. 2012 May;166(2):573-86. doi: 10.1111/j.1476-5381.2011.01790.x. PubMed PMID: 22122192; PubMed Central PMCID: PMC3417490.