TargetMol

BMX-010

Product Code:
 
TAR-T30546
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T30546-5mg5mgEnquire
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Further Information

Bioactivity:
BMX-010, also known as AEOL-10113, is Porphyrin-Based SOD Mimic.
CAS:
219818-60-7
Formula:
C48H44Cl5MnN8
Molecular Weight:
965.12
Purity:
0.98
SMILES:
[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Mn+3].CC[n+]1ccccc1-c1c2ccc(n2)c(-c2cccc[n+]2CC)c2ccc([n-]2)c(-c2cccc[n+]2CC)c2ccc(n2)c(-c2cccc[n+]2CC)c2ccc1[n-]2

References

1. Anselmo W, Branchetti E, Grau JB, Li G, Ayoub S, Lai EK, Rioux N, Tovmasyan A, Fortier JH, Sacks MS, Batinic-Haberle I, Hazen SL, Levy RJ, Ferrari G. Porphyrin-Based SOD Mimic MnTnBu OE -2-PyP(5+) Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis. J Am Heart Assoc. 2018 Oct 16;7(20):e007861. doi: 10.1161/JAHA.117.007861. PubMed PMID: 30371255. 2. Batinic-Haberle I, Tovmasyan A, Spasojevic I. Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury. Antioxid Redox Signal. 2018 Dec 1;29(16):1691-1724. doi: 10.1089/ars.2017.7453. Epub 2018 Aug 28. PubMed PMID: 29926755; PubMed Central PMCID: PMC6207162. 3. Bruni A, Pepper AR, Pawlick RL, Gala-Lopez B, Gamble A, Kin T, Malcolm AJ, Jones C, Piganelli JD, Crapo JD, Shapiro AMJ. BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. Am J Transplant. 2018 Aug;18(8):1879-1889. doi: 10.1111/ajt.14705. Epub 2018 Mar 31. PubMed PMID: 29464912. 4. Leu D, Spasojevic I, Nguyen H, Deng B, Tovmasyan A, Weitner T, Sampaio RS, Batinic-Haberle I, Huang TT. CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP(5). Redox Biol. 2017 Aug;12:864-871. doi: 10.1016/j.redox.2017.04.027. Epub 2017 Apr 22. PubMed PMID: 28454069; PubMed Central PMCID: PMC5407575.