TargetMol

CI-966

Product Code:
 
TAR-T30928
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T30928-5mg5mg£850.00
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TAR-T30928-50mg50mg£1,661.00
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Quantity:
TAR-T30928-100mg100mg£2,079.00
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  • Further Information
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Further Information

Bioactivity:
CI-966 is a central nervous system inhibitor, which is a highly selective inhibitor of GABA reuptake, especially GABA transporter 1 (GAT-1) (IC50 = 0.26 μ m). It has potential as an anticonvulsant, anxiety drug, and neuroprotective therapy.
CAS:
110283-79-9
Formula:
C23H22ClF6NO3
Molecular Weight:
509.87
Purity:
0.98
SMILES:
C1C(=CCC[N@@]1CCOC(c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(F)(F)F)C(=O)O.Cl

References

1. Phillis JW. CI-966, a GABA uptake inhibitor, antagonizes ischemia-induced neuronal degeneration in the gerbil. Gen Pharmacol. 1995 Sep;26(5):1061-4. PubMed PMID: 7557251. 2. Green AR, Hainsworth AH, Jackson DM. GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke. Neuropharmacology. 2000 Jul 10;39(9):1483-94. Review. PubMed PMID: 10854894. 3. Dhar TG, Borden LA, Tyagarajan S, Smith KE, Branchek TA, Weinshank RL, Gluchowski C. Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. J Med Chem. 1994 Jul 22;37(15):2334-42. PubMed PMID: 8057281. 4. Borden LA, Dhar TG, Smith KE, Branchek TA, Gluchowski C, Weinshank RL. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels. 1994;2(3):207-13. PubMed PMID: 7874447.