TargetMol

CP-339818

Product Code:
 
TAR-T31050
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31050-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T31050-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T31050-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
CP-339818 is of great value in immune system studies, where the loss of Kv1.4 makes it functionally selective to Kv1.3, and it has shown inhibition of T cell activation.
CAS:
185855-91-8
Formula:
C21H24N2
Molecular Weight:
304.437
Purity:
0.98
SMILES:
CCCCCN=c1ccn(Cc2ccccc2)c2ccccc12

References

1. Sforna L, D'Adamo MC, Servettini I, Guglielmi L, Pessia M, Franciolini F, Catacuzzeno L. Expression and function of a CP339,818-sensitive K? current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia. J Neurophysiol. 2015 Apr 1;113(7):2653-65. doi: 10.1152/jn.00379.2014. PubMed PMID: 25652918; PubMed Central PMCID: PMC4416569. 2. Jacobson DA, Mendez F, Thompson M, Torres J, Cochet O, Philipson LH. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J Physiol. 2010 Sep 15;588(Pt 18):3525-37. doi: 10.1113/jphysiol.2010.190207. PubMed PMID: 20643768; PubMed Central PMCID: PMC2988516. 3. Lee YT, Vasilyev DV, Shan QJ, Dunlop J, Mayer S, Bowlby MR. Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay. Eur J Pharmacol. 2008 Feb 26;581(1-2):97-104. PubMed PMID: 18162181. 4. J?ger H, Rauer H, Nguyen AN, Aiyar J, Chandy KG, Grissmer S. Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states. J Physiol. 1998 Jan 15;506 ( Pt 2):291-301. PubMed PMID: 9490854; PubMed Central PMCID: PMC2230732.