TargetMol

Foretinib

Product Code:
 
TAR-T3113
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3113-2mg2mg£97.00
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TAR-T3113-5mg5mg£112.00
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TAR-T3113-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T3113-10mg10mg£128.00
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TAR-T3113-25mg25mg£179.00
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TAR-T3113-50mg50mg£245.00
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TAR-T3113-100mg100mg£370.00
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TAR-T3113-500mg500mg£788.00
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This product comes from: United States.
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Further Information

Bioactivity:
Foretinib is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.
CAS:
849217-64-7
Formula:
C34H34F2N4O6
Molecular Weight:
632.665
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.998
SMILES:
COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Target:
VEGFR; Tie-2; c-Met/HGFR

References

1. Qian F, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res, 2009, 69(20), 8009-8016. 2. Kataoka Y, et al. Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest New Drugs, 2011. 3. Kogata Y, et al. Foretinib (GSK1363089) induces p53-dependent apoptosis in endometrial cancer. Oncotarget. 2018 Apr 27;9(32):22769-22784.