TargetMol

Dexoxadrol hydrochloride

Product Code:
 
TAR-T31403
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T31403-5mg5mg£850.00
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TAR-T31403-50mg50mg£1,661.00
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TAR-T31403-100mg100mg£2,079.00
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Further Information

Bioactivity:
Dexoxadrol Hydrochloride, a dissociative anesthetic, has been found to be an NMDA antagonist.
CAS:
631-06-1
Formula:
C20H24ClNO2
Molecular Weight:
345.87
Purity:
0.98
SMILES:
Cl.C1OC(O[C@H]1[C@@H]1CCCCN1)(c1ccccc1)c1ccccc1

References

1. Utech T, K?hler J, W?nsch B. Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and ? receptor antagonists. Eur J Med Chem. 2011 Jun;46(6):2157-69. doi: 10.1016/j.ejmech.2011.02.070. Epub 2011 Mar 5. PubMed PMID: 21444132. 2. Banerjee A, Schepmann D, K?hler J, W?rthwein EU, W?nsch B. Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists. Bioorg Med Chem. 2010 Nov 15;18(22):7855-67. doi: 10.1016/j.bmc.2010.09.047. Epub 2010 Sep 25. PubMed PMID: 20965735. 3. Sax M, Ebert K, Schepmann D, Wibbeling B, W?nsch B. Synthesis and NMDA-receptor affinity of 4-oxo-dexoxadrol derivatives. Bioorg Med Chem. 2006 Sep 1;14(17):5955-62. Epub 2006 Jun 5. PubMed PMID: 16750371. 4. Sax M, W?nsch B. Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity. Curr Top Med Chem. 2006;6(7):723-32. Review. PubMed PMID: 16719812.