TargetMol

Disoxaril

Product Code:
 
TAR-T31530
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31530-5mg5mg£850.00
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Quantity:
TAR-T31530-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T31530-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
Disoxaril (BRN 3626820, WIN 51711) is an anti-picornavirus agent that inhibits enterovirus replication by binding to a hydrophobic bag within the VP1 coat protein, thereby stabilizing virions and preventing their uncoating. When used in combination with Ambioxime and Bioxazole, there was a significant synergistic inhibition of poliovirus type 1 replication in FL cells.
CAS:
87495-31-6
Formula:
C20H26N2O3
Molecular Weight:
342.439
Purity:
0.98
SMILES:
Cc1cc(CCCCCCCOc2ccc(cc2)C2=NCCO2)on1

References

1. Nikolova I, Galabov AS, Petkova R, Chakarov S, Atanasov B. Disoxaril mutants of Coxsackievirus B1: phenotypic characteristics and analysis of the target VP1 gene. Z Naturforsch C. 2011 Nov-Dec;66(11-12):627-36. PubMed PMID: 22351989. 2. Ventura CA, Giannone I, Musumeci T, Pignatello R, Ragni L, Landolfi C, Milanese C, Paolino D, Puglisi G. Physico-chemical characterization of disoxaril-dimethyl-beta-cyclodextrin inclusion complex and in vitro permeation studies. Eur J Med Chem. 2006 Feb;41(2):233-40. Epub 2006 Jan 4. PubMed PMID: 16387393. 3. Nikolova I, Galabov AS. Development of resistance to disoxaril in Coxsackie B1 virus-infected newborn mice. Antiviral Res. 2003 Sep;60(1):35-40. PubMed PMID: 14516919. 4. Nikolaeva L, Galabov AS. Antiviral effect of the combination of enviroxime and disoxaril on coxsackievirus B1 infection. Acta Virol. 2000 Apr;44(2):73-8. PubMed PMID: 10989697.