TargetMol

Fosdevirine

Product Code:
 
TAR-T31860
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31860-5mg5mg£850.00
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TAR-T31860-50mg50mg£1,821.00
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Quantity:
TAR-T31860-100mg100mg£2,319.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Fosdevirine(GSK2248761, IDX899) is a Highly Potent inhibitor of Anti-HIV Non-nucleoside Reverse Transcriptase.
CAS:
1018450-26-4
Formula:
C20H17ClN3O3P
Molecular Weight:
413.79
Purity:
0.98
SMILES:
P(OC)(=O)(C=1C=2C(NC1C(N)=O)=CC=C(Cl)C2)C3=CC(/C=C/C#N)=CC(C)=C3

References

1. Dousson C, Alexandre FR, Amador A, Bonaric S, Bot S, Caillet C, Convard T, da Costa D, Lioure MP, Roland A, Rosinovsky E, Maldonado S, Parsy C, Trochet C, Storer R, Stewart A, Wang J, Mayes BA, Musiu C, Poddesu B, Vargiu L, Liuzzi M, Moussa A, Jakubik J, Hubbard L, Seifer M, Standring D. Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor. J Med Chem. 2016 Feb 3. [Epub ahead of print] PubMed PMID: 26804933. 2. Margolis DA, Eron JJ, DeJesus E, White S, Wannamaker P, Stancil B, Johnson M. Unexpected finding of delayed-onset seizures in HIV-positive, treatment-experienced subjects in the Phase IIb evaluation of fosdevirine (GSK2248761). Antivir Ther. 2014;19(1):69-78. doi: 10.3851/IMP2689. Epub 2013 Oct 24. PubMed PMID: 24158593. 3. ?lgen S. Recent development of new substituted indole and azaindole derivatives as anti-HIV agents. Mini Rev Med Chem. 2013 Oct;13(12):1700-8. Review. PubMed PMID: 23895189. 4. Castellino S, Groseclose MR, Sigafoos J, Wagner D, de Serres M, Polli JW, Romach E, Myer J, Hamilton B. Central nervous system disposition and metabolism of Fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: an LC-MS and Matrix-assisted laser desorption/ionization imaging MS investigation into central nervous system toxicity. Chem Res Toxicol. 2013 Feb 18;26(2):241-51. doi: 10.1021/tx3004196. Epub 2012 Dec 20. PubMed PMID: 23227887.