TargetMol

Freselestat

Product Code:
 
TAR-T31877
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31877-5mg5mg£1,412.00
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TAR-T31877-50mg50mg£2,785.00
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Quantity:
TAR-T31877-100mg100mg£3,765.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9. Freselestat reduces inflammatory mediators during simulated cardiopulmonary bypass.
CAS:
208848-19-5
Formula:
C23H28N6O4
Molecular Weight:
452.515
Purity:
0.98
SMILES:
CC(C)C(NC(=O)Cn1c(ncc(N)c1=O)-c1ccccc1)C(=O)c1nnc(o1)C(C)(C)C

References

1. Stevens T, Ekholm K, Gr?nse M, Lindahl M, Kozma V, Jungar C, Ottosson T, Falk-H?kansson H, Churg A, Wright JL, Lal H, Sanfridson A. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J Pharmacol Exp Ther. 2011 Oct;339(1):313-20. doi: 10.1124/jpet.111.182139. Epub 2011 Jul 26. PubMed PMID: 21791628. 2. Hirota Y, Suzuki M, Yamaguchi K, Fujita T, Katsube N. Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus). Comp Med. 2005 Feb;55(1):45-54. PubMed PMID: 15766209. 3. Hirota Y, Suzuki M, Yamaguchi K, Fujita T, Katsube N. Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters. J Vet Med Sci. 2004 Oct;66(10):1223-8. PubMed PMID: 15528853. 4. Yoshimura Y, Hiramatsu Y, Sato Y, Homma S, Enomoto Y, Jikuya T, Sakakibara Y. ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation. Ann Thorac Surg. 2003 Oct;76(4):1234-9. PubMed PMID: 14530017.