TargetMol

FTY720-Mitoxy

Product Code:
 
TAR-T31882
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31882-5mg5mg£850.00
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TAR-T31882-50mg50mg£1,661.00
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TAR-T31882-100mg100mg£2,079.00
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Further Information

Bioactivity:
FTY720-Mitoxy is an FTY720 analog that can be uesd as a novel stimulator of the activity of the protein phosphatase 2A (PP2A), targeting mitochondria.
CAS:
1604816-11-6
Formula:
C40H51BrNO3P
Molecular Weight:
704.73
Purity:
0.98
SMILES:
[Br-].CCCCCCCCc1ccc(CCC(CO)(CO)NC(=O)CC[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

References

1. Segura-Ulate I, Belcher TK, Vidal-Martinez G, Vargas-Medrano J, Perez RG. FTY720-derivatives do not induce FTY720-like lymphopenia. J Pharmacol Sci. 2017 Mar;133(3):187-189. doi: 10.1016/j.jphs.2017.02.006. Epub 2017 Feb 17. PubMed PMID: 28363412. 2. Enoru JO, Yang B, Krishnamachari S, Villanueva E, DeMaio W, Watanyar A, Chinnasamy R, Arterburn JB, Perez RG. Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy. PLoS One. 2016 Sep 9;11(9):e0162162. doi: 10.1371/journal.pone.0162162. eCollection 2016. PubMed PMID: 27611691; PubMed Central PMCID: PMC5017749. 3. Vargas-Medrano J, Krishnamachari S, Villanueva E, Godfrey WH, Lou H, Chinnasamy R, Arterburn JB, Perez RG. Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells. ACS Med Chem Lett. 2014 May 27;5(7):782-6. doi: 10.1021/ml500128g. eCollection 2014 Jul 10. PubMed PMID: 25050165; PubMed Central PMCID: PMC4094248.