TargetMol

HCV-371

Product Code:
 
TAR-T32050
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T32050-5mg5mg£850.00
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TAR-T32050-50mg50mg£1,661.00
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Quantity:
TAR-T32050-100mg100mg£2,079.00
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  • Further Information
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Further Information

Bioactivity:
HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ and other unrelated viral polymerases). This indicates that it is specific for HCV polymerase. Fluorescence binding studies have shown that HCV-371 binds to NS5b at an apparent dissociation constant of 150 nM, resulting in high selectivity and non-cytotoxicity in antiviral tests.
CAS:
675184-27-7
Formula:
C18H20N2O3
Molecular Weight:
312.369
Purity:
0.98
SMILES:
CCC[C@]1(CC(O)=O)OCCc2c1[nH]c1c(C)ccc(C#N)c21

References

1. Gopalsamy A, Lim K, Ciszewski G, Park K, Ellingboe JW, Bloom J, Insaf S, Upeslacis J, Mansour TS, Krishnamurthy G, Damarla M, Pyatski Y, Ho D, Howe AY, Orlowski M, Feld B, O'Connell J. Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6603-8. PubMed PMID: 15588095. 2. Howe AY, Bloom J, Baldick CJ, Benetatos CA, Cheng H, Christensen JS, Chunduru SK, Coburn GA, Feld B, Gopalsamy A, Gorczyca WP, Herrmann S, Johann S, Jiang X, Kimberland ML, Krisnamurthy G, Olson M, Orlowski M, Swanberg S, Thompson I, Thorn M, Del Vecchio A, Young DC, van Zeijl M, Ellingboe JW, Upeslacis J, Collett M, Mansour TS, O'Connell JF. Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase. Antimicrob Agents Chemother. 2004 Dec;48(12):4813-21. PubMed PMID: 15561861; PubMed Central PMCID: PMC529219.