TargetMol

HX-603

Product Code:
 
TAR-T32107
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32107-5mg5mg£850.00
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Quantity:
TAR-T32107-50mg50mg£1,661.00
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Quantity:
TAR-T32107-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
HX-603 is a selectivity agonist of RXR that inhibits the activation of RAR-RXR heterodimers as well as RXR homodimers.
CAS:
259228-72-3
Formula:
C31H34N2O2
Molecular Weight:
466.625
Purity:
0.98
SMILES:
CCCN1c2ccccc2N=C(c2ccc(cc2)C(O)=O)c2cc3c(cc12)C(C)(C)CCC3(C)C

References

1. Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, de Madariaga A, Domingo JC. 9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the
9cRA activities, and precludes them to mature phenotype development. J Immunol. 2007 May 15;178(10):6130-9. PubMed PMID: 17475839. 2. Varley CL, Stahlschmidt J, Smith B, Stower M, Southgate J. Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells. Am J Pathol. 2004 May;164(5):1789-98. PubMed PMID: 15111325; PubMed Central PMCID: PMC1615665. 3. Kagechika H. Novel synthetic retinoids and separation of the pleiotropic retinoidal activities. Curr Med Chem. 2002 Mar;9(5):591-608. Review. PubMed PMID: 11945126. 4. Ebisawa M, Umemiya H, Ohta K, Fukasawa H, Kawachi E, Christoffel G, Gronemeyer H, Tsuji M, Hashimoto Y, Shudo K, Kagechika H. Retinoid X receptor-antagonistic diazepinylbenzoic acids. Chem Pharm Bull (Tokyo). 1999 Dec;47(12):1778-86. PubMed PMID: 10748721.