TargetMol

Isoline

Product Code:
 
TAR-T32215
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32215-5mg5mg£850.00
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Further Information

Bioactivity:
Isoline is a pyrrolizidine alkaloid isolated from the traditional Chinese medicine Ligularia duciformis.
CAS:
30000-36-3
Formula:
C20H29NO7
Molecular Weight:
395.452
Purity:
0.98
SMILES:
[H][C@]12CCN3CC=C(COC(=O)[C@@](C)(OC(C)=O)[C@H](C)C[C@](O)(CC)C(=O)O1)[C@]23[H]

References

1. Chen Y, Ji L, Xiong A, Yang L, Wang Z. Involvement of intracellular glutathione in regulating isoline-induced cytotoxicity in human normal liver L-02 cells. Toxicol Ind Health. 2013 Jul;29(6):567-75. doi: 10.1177/0748233712442707. Epub 2012 Apr 2. PubMed PMID: 22474030. 2. Wang ZY, Kang H, Ji LL, Yang YQ, Liu TY, Cao ZW, Morahan G, Wang ZT. Proteomic characterization of the possible molecular targets of pyrrolizidine alkaloid isoline-induced hepatotoxicity. Environ Toxicol Pharmacol. 2012 Sep;34(2):608-617. doi: 10.1016/j.etap.2012.06.013. Epub 2012 Jul 6. PubMed PMID: 22885678. 3. Holderbaum DF, Cuhra M, Wickson F, Orth AI, Nodari RO, B?hn T. Chronic Responses of Daphnia magna Under Dietary Exposure to Leaves of a Transgenic (Event MON810) Bt-Maize Hybrid and its Conventional Near-Isoline. J Toxicol Environ Health A. 2015;78(15):993-1007. doi: 10.1080/15287394.2015.1037877. PubMed PMID: 26262442; PubMed Central PMCID: PMC4566889. 4. Liu TY, Chen Y, Wang ZY, Ji LL, Wang ZT. Pyrrolizidine alkaloid isoline-induced oxidative injury in various mouse tissues. Exp Toxicol Pathol. 2010 May;62(3):251-7. doi: 10.1016/j.etp.2009.04.008. Epub 2009 Jun 21. PubMed PMID: 19540740.