TargetMol

Paritaprevir

Product Code:
 
TAR-T3226
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3226-5mg5mg£105.00
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TAR-T3226-10mg10mg£117.00
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TAR-T3226-1mL1 mL * 10 mM (in DMSO)£140.00
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TAR-T3226-25mg25mg£143.00
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TAR-T3226-50mg50mg£196.00
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TAR-T3226-100mg100mg£297.00
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Quantity:
TAR-T3226-200mg200mg£479.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Paritaprevir is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential activity against HCV genotype 1. Upon administration, paritaprevir reversibly binds to the active center and binding site of the HCV NS3/NS4A protease and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both the processing of viral proteins and the formation of the viral replication complex, which inhibits viral replication in HCV genotype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavage of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family, and infection is associated with the development of hepatocellular carcinoma (HCC).
CAS:
1221573-85-8
Formula:
C40H43N7O7S
Molecular Weight:
765.89
Pathway:
Microbiology/Virology; Proteases/Proteasome
Purity:
0.9957
SMILES:
Cc1cnc(cn1)C(=O)N[C@H]1CCCCCC=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C1=O)Oc1nc2ccccc2c2ccccc12)C(=O)NS(=O)(=O)C1CC1
Target:
HCV Protease

References

1. Smith, M., & Lim, A. (2015). Profile of paritaprevir/ritonavir/ombitasvir plus dasabuvir in the treatment of chronic hepatitis C virus genotype 1 infection.?Drug Design, Development And Therapy, 6083. doi: 10.2147/dddt.s80226 2. Schnell G, et al. Hepatitis C Virus Genotype 4 Resistance and Subtype Demographic Characterization of Patients Treated with Ombitasvir plus Paritaprevir/ritonavir. Antimicrob Agents Chemother. 2015 Aug 17. pii: AAC.01229-15.