TargetMol

Jimenezin

Product Code:
 
TAR-T32290
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32290-5mg5mg£850.00
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TAR-T32290-50mg50mg£1,661.00
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TAR-T32290-100mg100mg£2,079.00
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  • Further Information
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Further Information

Bioactivity:
Jimenezin is a type of annonaceous acetogenin. As waxy derivatives of fatty acids (usually C32 or C34), annonaceous acetogenins contain a terminal carboxylic acid and a 2-propanol unit at the C-2 position to form a methyl- substituted alpha,beta-unsaturated-gamma-lactone. One of their structural features is tetrahydrofuran (THF) or tetrahydropyran (THP) system with one or two flanking hydroxyl group(s) at the center of a long hydrocarbon chain. Jimenezin is a very weakly acidic compound (based on its pKa) and appears practically insoluble (in water). Jimenezin exists in alcoholic beverages and fruits. It can be used as a potential biomarker during the consumption of these food products. Jimenezin exists in alcoholic beverages and it is a constituent of the seeds of Rollinia mucosa (biriba).
CAS:
204185-17-1
Formula:
C37H66O7
Molecular Weight:
622.928
Purity:
0.98
SMILES:
CCCCCCCCCC[C@@H]1O[C@@H](CC[C@H]1O)[C@H]1CC[C@@H](O1)[C@H](O)CCCCCCCCCC[C@@H](O)CC1=C[C@H](C)OC1=O

References

1. Matsui Y, Takeuchi T, Kumamoto-Yonezawa Y, Takemura M, Sugawara F, Yoshida H, Mizushina Y. The relationship between the molecular structure of natural acetogenins and their inhibitory activities which affect DNA polymerase, DNA topoisomerase and human cancer cell growth. Exp Ther Med. 2010 Jan;1(1):19-26. Epub 2010 Jan 1. PubMed PMID: 23136587; PubMed Central PMCID: PMC3490394. 2. Takahashi S, Yonezawa Y, Kubota A, Ogawa N, Maeda K, Koshino H, Nakata T, Yoshida H, Mizushina Y. Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. Int J Oncol. 2008 Feb;32(2):451-8. PubMed PMID: 18202768. 3. Bandur NG, Br?ckner D, Hoffmann RW, Koert U. Total synthesis of jimenezin via an intramolecular allylboration. Org Lett. 2006 Aug 17;8(17):3829-31. PubMed PMID: 16898828. 4. Takahashi S, Maeda K, Hirota S, Nakata T. Total synthesis of a new cytotoxic acetogenin, jimenezin, and the revised structure. Org Lett. 1999 Dec 16;1(12):2025-8. PubMed PMID: 10905863.