TargetMol

JS-38

Product Code:
 
TAR-T32316
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32316-5mg5mg£850.00
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Further Information

Bioactivity:
JS-38 is a synthetic version of a metabolite isolated from Xenorhabdus sp.
CAS:
608131-69-7
Formula:
C22H14F6N2O4S2
Molecular Weight:
548.47
Purity:
0.98
SMILES:
COc1ccc(c(OC)c1)-n1c2cssc2c(NC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1=O

References

1. Liu MY, Xiao L, Chen GH, Wang YX, Xiong WX, Li F, Liu Y, Huang XL, Deng YF, Zhang Z, Sun HY, Liu QH, Yin M. Oral JS-38, a metabolite from Xenorhabdus sp., has both anti-tumor activity and the ability to elevate peripheral neutrophils. Chin J Nat Med. 2014 Oct;12(10):768-76. doi: 10.1016/S1875-5364(14)60117-5. Epub 2014 Oct 31. PubMed PMID: 25443370. 2. Zhang H, Liu Q, Fan T, Fang Y, Li Y, Wang G. Metabolism and disposition of a novel antineoplastic JS-38 (Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5- bis (trifluoromethyl)-(9Cl)) in rats. Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):45-56. doi: 10.1007/s13318-011-0055-8. Epub 2011 Jul 30. PubMed PMID: 21805208. 3. Ng HZ, Fang Y, Li Y, Fan TT, Qin Y, Liu QH. The pharmacokinetics of JS-38, a novel antineoplastic drug, in rats. Eur J Drug Metab Pharmacokinet. 2008 Jul-Sep;33(3):143-8. PubMed PMID: 19007039.