TargetMol

KLS-13019

Product Code:
 
TAR-T32402
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32402-5mg5mg£930.00
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TAR-T32402-50mg50mg£1,821.00
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TAR-T32402-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
KLS-13019 is a Cannabidiol-Derived Neuroprotective Agent with Improved Potency, Safety, and Permeability. (EC50=40nM; T1=7500). KLS-13019 was 50-fold more potent and >400-fold safer than cannabidiol and exhibited an in vitro profile consistent with improved oral bioavailability. KLS-13019 was only toxic at 300 μM giving it a therapeutic index of 7500.
CAS:
1801243-39-9
Formula:
C22H29NO3
Molecular Weight:
355.478
Purity:
0.98
SMILES:
CC(=C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CC2CN(C2)C(C)=O)cc1O

References

1. Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability. William A. Kinney, Mark E. McDonnell, Hua Marlon Zhong, Chaomin Liu, Lanyi Yang, Wei Ling, Tao Qian, Yu Chen, Zhijie Cai, Dean Petkanas, and Douglas E. Brenneman? Publication Date (Web): February 10, 2016 (Letter)? DOI: 10.1021/acsmedchemlett.6b00009