TargetMol

Leinamycin

Product Code:
 
TAR-T32624
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T32624-5mg5mg£850.00
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Further Information

Bioactivity:
Leinamycin is a thiazole containing macrolide that is extracted from Streptomyces possibly used as a DNA alkylator.
CAS:
120500-15-4
Formula:
C22H26N2O6S3
Molecular Weight:
510.64
Purity:
0.98
SMILES:
CC1NC(=O)CC2(CCC(C)=CC(O)C(=O)C=C/C=C/c3csc1n3)S(=O)SC(=O)C2(C)O

References

1. Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, Lohman JR, Tang GL, Ju J, Liu T, Wilding G, Shen B. Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8278-83. doi: 10.1073/pnas.1506761112. Epub 2015 Jun 8. PubMed PMID: 26056295; PubMed Central PMCID: PMC4500275. 2. Keerthi K, Rajapakse A, Sun D, Gates KS. Synthesis and characterization of a small analogue of the anticancer natural product leinamycin. Bioorg Med Chem. 2013 Jan 1;21(1):235-41. doi: 10.1016/j.bmc.2012.10.021. Epub 2012 Oct 27. PubMed PMID: 23168080; PubMed Central PMCID: PMC3532941. 3. Viswesh V, Hays AM, Gates K, Sun D. DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences. Bioorg Med Chem. 2012 Jul 15;20(14):4413-21. doi: 10.1016/j.bmc.2012.05.033. Epub 2012 May 23. PubMed PMID: 22682923; PubMed Central PMCID: PMC3389147. 4. Katt WP, Cerione RA. Less than the sum of its parts, a leinamycin precursor has superior properties. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8164-5. doi: 10.1073/pnas.1510122112. Epub 2015 Jun 23. PubMed PMID: 26106161; PubMed Central PMCID: PMC4500279.